Curtis J Henrich Selected Research

Neoplasms (Cancer)

1/2021	Small-Molecule Natural Product Physachenolide C Potentiates Immunotherapy Efficacy by Targeting BET Proteins.
10/2017	Identification of Natural Products That Inhibit the Catalytic Function of Human Tyrosyl-DNA Phosphodiesterase (TDP1).
1/2016	Diaryl Disulfides as Novel Stabilizers of Tumor Suppressor Pdcd4.
1/2016	Inhibition of wnt/β-catenin Signaling in Hepatocellular Carcinoma by an Antipsychotic Drug Pimozide.
4/2015	Structural Elucidation and Synthesis of Eudistidine A: An Unusual Polycyclic Marine Alkaloid that Blocks Interaction of the Protein Binding Domains of p300 and HIF-1α.
8/2014	Tricyclic guanidine alkaloids from the marine sponge Acanthella cavernosa that stabilize the tumor suppressor PDCD4.
4/2014	Characterization of pomiferin triacetate as a novel mTOR and translation inhibitor.
1/2012	Erioflorin stabilizes the tumor suppressor Pdcd4 by inhibiting its interaction with the E3-ligase β-TrCP1.
1/2012	Effects of cucurbitacins on cell morphology are associated with sensitization of renal carcinoma cells to TRAIL-induced apoptosis.
9/2011	Actinopolysporins A-C and tubercidin as a Pdcd4 stabilizer from the halophilic actinomycete Actinopolyspora erythraea YIM 90600.

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Curtis J Henrich Research Topics

Disease

13	Neoplasms (Cancer) 01/2021 - 03/2006
5	Renal Cell Carcinoma (Grawitz Tumor) 01/2021 - 01/2012
2	Hepatocellular Carcinoma (Hepatoma) 01/2016 - 08/2013
2	Colonic Neoplasms (Colon Cancer) 01/2016 - 11/2014
2	Neurofibromatosis 1 (Neurofibromatosis Type I) 02/2014 - 01/2013
1	Merkel Cell Carcinoma 08/2023
1	Infections 01/2023
1	COVID-19 01/2023
1	Osteosarcoma (Osteogenic Sarcoma) 01/2021
1	Melanoma (Melanoma, Malignant) 01/2021
1	Experimental Melanoma 01/2021
1	Neoplasm Metastasis (Metastasis) 01/2021
1	Marginal Zone B-Cell Lymphoma (MALT Lymphoma) 05/2020
1	Lung Neoplasms (Lung Cancer) 10/2017
1	Hypoxia (Hypoxemia) 04/2015
1	Carcinoma (Carcinomatosis) 11/2014
1	Breast Neoplasms (Breast Cancer) 03/2009

Drug/Important Bio-Agent (IBA)

4	AlkaloidsIBA 08/2023 - 02/2014
3	Proteins (Proteins, Gene)FDA Link 01/2021 - 04/2015
2	LigandsIBA 01/2021 - 01/2017
2	LuciferasesIBA 01/2016 - 01/2012
2	Epithelial Cell Adhesion MoleculeIBA 01/2016 - 08/2013
2	PhytochemicalsIBA 02/2014 - 01/2013
2	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 01/2012 - 02/2007
1	LectinsIBA 01/2023
1	cyanovirin NIBA 01/2023
1	Glycoproteins (Glycoprotein)IBA 01/2023
1	OligosaccharidesIBA 01/2023
1	Polysaccharides (Glycans)IBA 01/2023
1	Poly I-CIBA 01/2021
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2021
1	LimoninsIBA 01/2021
1	physachenolide CIBA 01/2021
1	cerivastatin (Kazak)FDA Link 01/2021
1	PolynucleotidesIBA 01/2021
1	Peptide Hydrolases (Proteases)FDA Link 05/2020
1	rocaglamideIBA 11/2018
1	Type I DNA Topoisomerases (Topoisomerase I)IBA 10/2017
1	CamptothecinIBA 10/2017
1	WithanolidesIBA 01/2017
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2017
1	discorhabdin WIBA 01/2016
1	discorhabdin HIBA 01/2016
1	makaluvamine FIBA 01/2016
1	discorhabdin LIBA 01/2016
1	discorhabdin BIBA 01/2016
1	DisulfidesIBA 01/2016
1	Pimozide (Orap)FDA Link 01/2016
1	Protein Synthesis InhibitorsIBA 01/2016
1	Antipsychotic Agents (Antipsychotics)IBA 01/2016
1	CateninsIBA 01/2016
1	Transcription Factors (Transcription Factor)IBA 04/2015
1	Molecular Probes (Molecular Probe)IBA 04/2015
1	Oxygen (Dioxygen)IBA 04/2015
1	Hypoxia-Inducible Factor 1IBA 04/2015
1	mirabilin GIBA 08/2014
1	Guanidine (Guanidine Nitrate)FDA Link 08/2014
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 04/2014
1	Ribosomal Protein S6 Kinases (S6 Kinase)IBA 04/2014
1	Sirolimus (Rapamycin)FDA Link 04/2014
1	4- (5- acetyloxy- 8,8- dimethyl- 6- (3- methylbut- 2- en- 1- yl)- 4- oxo- 4,8- dihydropyrano(2,3- f)chromen- 3- yl)- 1,2- phenylene diacetateIBA 04/2014
1	QuassinsIBA 02/2014
1	LignansIBA 02/2014
1	Complex MixturesIBA 01/2012
1	CucurbitacinsIBA 01/2012
1	Apoptosis Regulatory ProteinsIBA 09/2011
1	NF-kappa B (NF-kB)IBA 03/2009
1	2- (4- ((4- amino- 2- methylphenyl)diazenyl)phenylsulfonyl)ethanesulfonoperoxoic acidIBA 03/2009
1	matrigelIBA 03/2009
1	Adenosine Triphosphate (ATP)IBA 03/2006
1	Cytotoxins (Cytolysins)IBA 03/2006

Therapy/Procedure

3	Therapeutics 01/2016 - 02/2007
1	Immunotherapy 01/2021